醫學研究中心
張慧東
職稱:研究員
科室:醫學研究中心
出診安排
星期一 星期二 星期三 星期四 星期五 星期六 星期日
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簡介

中山大學附屬八院研究員,博士生導師,醫學研究中心副主任(主持工作)。曾入選/獲得中組部“千人計劃”(青年項目)(2014)、自然科學基金委優秀青年科學基金(2015)、遼寧省科技獎勵一等獎(2015)、中國毒理學會優秀青年科技獎(2016)、四川省衛計委領軍人才(2017)、四川省特聘專家(2017)、四川大學青年科技人才獎(2017)、四川省衛健委學術技術帶頭人(2018)、四川省專家評議(審)委員會(2020)、四川省學術技術帶頭人(2020)、中山大學百人計劃中青年杰出人才(2021)、深圳市高層次專業人才(2021)等。

近五年(2016-2021),圍繞“環境和復發性流產主題(屬于公共衛生和預防醫學/衛生毒理學),主要從事非編碼RNA在環境有害因素導致女性滋養層細胞功能障礙而引發流產中的作用和調控機制研究,在面上、優青、科技部重點專項、千人計劃等17項基金的資助下,以第一或通訊作者(含共同)在Nucleic Acids Res (IF: 11.561,2篇)、J Biol Chem (Nature Index)、Cell Biol Toxicol (IF: 6.691,3篇)、Sci Total Environ (IF: 7.963)、Environ. Pollut (IF: 6.792)、Ecotoxicol Environ Saf (IF: 6.291)等國際知名雜志上發表SCI論文42篇,發表中文核心期刊論文7篇。被Science、Nat Commun、Ann Rev Biochem、PNAS等國際著名期刊正面評價及引用544次(至2022.02.09, Web of Science)。至今,以第一或通訊作者累計發表SCI論文61篇,累計被引1261次(至2022.02.09, Web of Science)。

受Springer出版社邀請獨立撰寫關于“DNA Replication-Damage from Environmental Carcinogens的Briefs(2015)。受本領域國際著名雜志Mutat Res RevCrit Rev Biochem Mol邀請,綜述本團隊最新的研究進展及展望國際研究熱點(2016和2020)。受邀Genes雜志邀請,撰寫DNA replication control的???017)。受《環境和職業醫學》雜志邀請組稿“環境和女性生殖健康”的???019)。受Springer Nature出版社邀請作為主編出版PubMed收錄的“Environment and Female Reproductive Health”英文叢書,Advances in Experimental Medicine and Biology 1300 (IF: 2.450; 2021)。受邀參加6th International Conference on Biomedical and Environmental Sciences & Technology (icBEST-2016) 和the 7th international symposium on DNA Damage Response & Human Disease (isDDRHD-2016)的國際研討會和第四屆毒性測試替代方法與轉化毒理學(國際)學術研討會(2018),并做口頭報告。受邀參加中國毒理學會議(2017、2019),中國誘變劑學術會議(2017、2019)、全國環境與健康學術會議(2018、2019、2020、2021)、全國衛生檢驗學術交流大會(2021)、第三屆全國母胎醫學大會(2021)、第十一屆環境化學大會(2021),并做口頭或主旨報告。負責組織并籌辦基因不穩定與疾病防治高峰論壇(2016,重慶)和第三屆全國現代生物物理方法與技術暨國際單分子生物學研討會(2020,成都)。

擔任中華預防醫學會衛生毒理學專委會、中國誘變劑學會青年委員會、中國康復醫學會生殖健康專業委員會、中華預防醫學會衛生檢驗委員會、中國生物化學和分子生物學酶學委員會等12個國家一級或二級專委會的委員或常務委員。擔任《環境與職業醫學》雜志常務編委。擔任國家基金委自然科學基金、國家科技部重點研發計劃重點專項、國家科技獎勵的評審專家;擔任波蘭國家科學中心和重慶市、四川省、江蘇省、河北省、廣東省和貴州省科技項目評審專家;擔任廣東省科學技術獎評審專家;擔任教育部學位與研究生教育發展中心學科評估專家(第四、五輪);擔任高等學??茖W研究優秀成果獎(科學技術)、教育部學位中心博士碩士學位論文、國家留學基金委公派研究生項目評審專家。擔任Nucleic Acids Res、Sci Total Environ、Toxicol Sci等16個國際知名雜志的審稿人。

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聯系方式

廣東省深圳市福田區福明路18號 中大八院醫技樓308

廣東 深圳,518033,中國

zhanghd29@mail.sysu.edu.cn

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研究方向

主要進行環境和女性生殖健康領域的研究,針對臨床上的多種女性生殖疾病,例如復發性流產、宮內生長受限、子癇等多種疾病,揭示非編碼RNA在環境有害因素導致女性滋養層細胞功能障礙而引發復發性流產中的作用和調控機制,探究女性生殖疾病的發病的原因和內在分子機制,并尋求在臨床上預防或治療疾病的新途徑。

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榮譽獎勵

  • 2021.06,入選深圳市高層次專業人才(地方級)

  • 2021.01,入選中山大學“百人計劃”中青年杰出人才

  • 2020.12,入選第十三批四川省學術技術帶頭人

  • 2020.06,入選四川省專家評議(審)委員會

  • 2018.12,入選四川省衛生健康委學術技術帶頭人

  • 2018.04,獲2017年度四川大學青年科技人才獎

  • 2018.01,入選四川省青年千人計劃

  • 2018.01,獲四川省衛生計生委領軍人才

  • 2016.08,獲中國毒理學會優秀青年科技獎

  • 2015.12,獲遼寧省科學技術獎勵一等獎,納米空間中的多相手性催化研究

  • 2015.01,獲國家自然科學基金委國家優秀青年科學基金資助

  • 2014.01,入選中組部第十一批國家“千人計劃”(青年項目)

  • 2013.10,獲2013年中國微生物學會學術年會“優秀學術論文獎”

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發表論文(citation till 20220308)

【2022

79.Lnc-HZ03 promotes TRBP-mediated splicing of pre-miR-hz03 to generate miR-hz03 in human trophoblast cells.? Jingsong Zhao#, Tingting Liang#, Jiayu Xie#, Rong Wang, Weina Chen, Chenglong Ma, Xinying Huang, Lin Ao* and Huidong Zhang*.? Acta Biochim. Biophys. Sin., 2022, In press. ?(1745-7270; Q3; IF: 3.848; )

78.Novel lncRNA-HZ05 regulates BPDE-inhibited human trophoblast cell proliferation and the occurrence of abortion by inhibiting FOXO3a/P21/CDK2 pathway through competitively binding with miR-hz05.? Chenyang Mi, Weina Chen, Tingting Liang, Jiayu Xie, Zhongyan Xu, Wenxin Huang, Peng Tian, Shuming Zhang, Mengyuan Dai, and Huidong Zhang*.? Cell Biol. Toxicol. 2022, In press. (doi: 10.1007/s10565-021-09687-w; Q1; IF: 6.691; 0 times)

【2021

77. BPDE induces human trophoblast cell ferroptosis by up-regulating iron metabolism and promoting GPX4 proteasomal degradation.? Peng Tian#, Zhongyan Xu#, Jiarong Guo, Jingsong Zhao, Rong Wang, Weina Chen, Yang Yang, Wenxin Huang, Chenyang Mi, and Huidong Zhang*.? Ecotoxicol. Environ. Saf.. 2021, 228: 113028.? (https://doi.org/10.1016/j.ecoenv.2021.113028; Q1; IF: 6.291; 0 times).?

76.Novel lncRNA-HZ04 promotes BPDE-induced human trophoblast cell apoptosis and abortion by up-regulating IP3R1/CaMKII/SGCB pathway by competitively binding with miR-hz04.? Wenxin Huang#, Mengyuan Dai#, Chenyang Mi, Tingting Liang, Taotao Qiu, Zhongyan Xu, Jiayu Xie, Weina Chen, Peng Tian, Shuming Zhang, and Huidong Zhang*. ?FASEB J., 2021, 35: e21789. (1530-6860; doi:10.1096/fj.202100376RR; Biology Q1; IF: 5.191; 2 times)

75. Environmental pollutant benzo[a]pyrene upregulated long non-coding RNA HZ07 inhibits trophoblast cell migration by inactivating PI3K/AKT/MMP2 signaling pathway in recurrent pregnancy Loss. ?Yang Ye#, Sushi Jiang#, Chenyang Mi, Tao Du, Tingting Liang, Huan Zhong, Jiayu Xie, Wenming Xu, Huidong Zhang*, and Xiaomiao Zhao*. ?Reprod. Sci., 2021, 28(11):3085-3093.? (1933-7205; https://doi.org/10.1007/s43032-021-00630-2; Obstetrics & Gynecology Q3; IF: 2.616; 1 times)

74. Environment and Female Reproductive Health, Advances in Experimental Medicine and Biology 1300, Editor, Springer Nature. 2021. (Invited Book; 0065-2598; https://doi.org/10.1007/978-981-33-4187-6; IF: 2.450)

73. DNA Polymerase Gp90 Activities and Regulations on Strand Displacement DNA Synthesis Revealed at Single-molecule Level.? Shuming Zhang, Xue Xiao, Jingwei Kong, Ke Lu, Shuo-Xing Dou, Peng-Ye Wang, Lu Ma, Yuru Liu, Guohong Li, Wei Li* and Huidong Zhang*. ?FASEB J. 2021, 35, e21607. (1530-6860; DOI: 10.1096/fj.202100033RR; Biology Q1; IF: 5.191; 0 times) ?

72. Upregulated lnc-HZ02 and miR-hz02 inhibited migration and invasion by down-regulating FAK/SRC/PI3K/AKT pathway in BPDE-treated trophoblast cells.? Jiarong Guo#, Rui Li#, Zhongyan Xu#, Peng Tian, Rong Wang, Youzhu Li, Xia Qiu, Peng Zou, Mei He, Lin Ao*, Qicai Liu*, and Huidong Zhang*. J. Biochem. Mol. Toxicol. 2021, e22757. (DOI: https://doi.org/10.1002/jbt.22757; Toxicology Q3; IF: 3.606; 1 times).

71. Lnc-HZ08 regulates BPDE-induced trophoblast cell dysfunctions by promoting PI3K ubiquitin degradation and is assciated with miscarriage.? Jiayu Xie#, Tingting Liang#, Jingsong Zhao, Zhongyan Xu, Peng Tian, Rong Wang, Chenyang Mi, Wenxin Huang, Weina Chen, Huidong Zhang*. Cell Biol. Toxicol. 2021, In press.? (0742-2091; Doi.org/10.1007/s10565-021-09606-z; Q1; IF: 6.691; 3 times)

70. Lnc-HZ01 with m6A RNA methylation inhibits human trophoblast cell proliferation and induces miscarriage by up-regulating BPDE-activated lnc-HZ01/MXD1 positive feedback loop.? Zhongyan Xu#, Peng Tian#, Jiarong Guo, Chenyang Mi, Tingting Liang, Jiayu Xie, Wenxin Huang, Mengyuan Dai, Weina Chen, and Huidong Zhang*. ?Sci. Total Environ. 2021, 776:145950. ?(0048-9697; DOI: https://doi.org/10.1016/j.scitotenv.2021.145950; Q1; IF: 6.938; Cited 7 times)

69. LncRNA HOTAIR促進女性滋養層細胞遷移的機制。許仲妍,郭佳蓉,田鵬,鄧思思,張慧東*?,F代預防醫學,2021,48,1272-1276。

68. MiR-184促進滋養層細胞凋亡而引起復發性流產的研究。梁婷婷,趙靖嵩,馬成龍,楊陽,武雅婷,謝嘉渝,張慧東*?,F代預防醫學,2021,48,1123-1127。

67. LncRNA NEAT1抑制女性滋養層細胞增殖的研究。謝嘉渝,馬成龍,趙靖嵩,武雅婷,楊陽,梁婷婷,張慧東*?,F代預防醫學,2021,48,911-915。

66. Novel lnc-HZ03 and miR-hz03 promote BPDE-induced human trophoblast cell apoptosis and induce miscarriage by upregulating p53/SAT1 pathway.? Tingting Liang#, Jiayu Xie#, Jingsong Zhao, Wenxin Huang, Zhongyan Xu, Peng Tian, Chenyang Mi, Mengyuan Dai, Shuming Zhang, and Huidong Zhang*. Cell Biol. Toxicol. 2021, 37(6):951-970.? (0742-2091; DOI:https://doi.org/10.1007/s10565-021-09583-3; Q1; IF: 6.691; 4 times).?

【2020】

65. Predicting the animal susceptibility and drugs to SARS-CoV-2 based on Spike glycoprotein combined with ACE2.? Min Shen, Chao Liu, Run Xu, Zijing Ruan, Shiying Zhao, Huidong Zhang, Wang Wen, Xinhe Huang, Li Yang, Yong Tang, Tai Yang, Xu Jia*.? Frontiers in Genetics, section Computational Genomics. ?2020, In Press. DOI.org/10.3389/fgene.2020.575012; 6 times

64. Environmental Pollutant Benzo[a]pyrene Induces Recurrent Pregnancy Loss through Promoting Apoptosis and Suppressing Migration of Extravillous Trophoblast. Yang Ye, Sushi Jiang, Chao Zhang, Tao Du, Huan Zhong, Wenming Xu, Huidong Zhang* and Xiaomiao Zhao*. BioMed Res. Int. 2020, 8983494. DOI: doi.org/10.1155/2020/8983494. (2314-6133, IF: 2.276; Cited 5 times; Biochemistry & Molecular Biology Q2)

63. Mechanisms of mutagenesis induced by DNA lesions: multiple factors affect mutations in translesion DNA synthesis. Huidong Zhang*. Crit. Rev. Biochem. Mol. Biol., 55: 219-251, 2020. DOI: 10.1080/10409238.2020.1768205.(Invited; 1040-9238, IF: 7.634; Cited 2 times; Biochemistry & Molecular Biology Q2; )

62. Dynamic structural insights into the molecular mechanism of DNA unwinding by the bacteriophage T7 helicase. Jianbing Ma#, Ze Chen#, Chunhua Xu#, Xingyuan Huang, Qi Jia,Zhenyu Zou, Chenyang Mi,Dongfei Ma, Ying Lu*, Huidong Zhang*, and Ming Li*. Nucleic Acids Res., 48: 3156-3164, 2020. DOI: 10.1093/nar/gkaa057.(0305-1048, IF: 11.561; Cited 4 times; Biology Q1; )

61. Strand-displacement DNA synthesis by DNA polymerase gp90 exo- of Pseudomonas aeruginosa phage 1. Chenyang Mi#, Shuming Zhang#, Wenxin Huang, Mengyuan Dai, Zili Chai, Wang Yang, Shanshan Deng, Lin Ao*, and Huidong Zhang*.Biochimie,170: 73-87, 2020. DOI: 10.1016/j.biochi.2019.12.013. (0300-9084, IF: 3.362; Cited 2 times; Biochemistry & Molecular Biology Q3; )

60. Epigenetically modified N6-methyladesine inhibits DNA replication by human DNA Polymerase iota. Shuming Zhang, Bianbian Li, Ke Du, Tingting Liang, Mengyuan Dai, Wenxin Huang, Huizhi Zhang, Yihui Ling, and Huidong Zhang*. Biochimie, 168: 134-143, 2020. DOI: 10.1016/j.biochi.2019.10.018 (0300-9084, IF: 3.362; Cited 3 times; Biochemistry & Molecular Biology Q3)

【2019】

59. Epigenetic DNA Modification N6-methyladenine inhibits DNA replication bySulfolobus solfataricus Y-family DNA Polymerase Dpo4. Ke Du, Shuming Zhang, Weina Chen, Mengyuan Dai, Zhongyan Xu, Tingting Liang, Wenxin Huang, Yihui Ling, and Huidong Zhang*. Arch. Biochem. Biophys., 675: 108-120, 2019. DOI: 10.1016/j.abb.2019.108120. (0003-9861, IF: 3.559; Cited 2 times; Biochemistry & Molecular Biology Q3)

58. Ribonucleoside Triphosphates Promote T7 DNA Replication and the Lysis of T7-Infected Escherichia coli. Zhenyu Zou, Wendi Xu, Chenyang Mi, Ying Xu, Ke Du, Bianbian Li, Yang Ye, Yihui Ling, and Huidong Zhang*. Biochimie, 167: 25-33, 2019. DOI: 10.1016/j.biochi.2019.09.002. (0300-9084, IF: 3.362; Cited 1 times; Biochemistry & Molecular Biology Q3)

57. Protein Interactions in T7 DNA Replisome Inhibit the Bypass of Abasic Site by DNA polymerase. Zhenyu Zou, Tingting Liang, Zhongyan Xu, Jiayu Xie, Shuming Zhang, Weina Chen, Siqi Wan, Yihui Ling, and Huidong Zhang*. Mutagenesis, 34: 355-361, 2019. DOI:10.1093/mutage/gez013.(IF: 2.898; Cited 1 times; Biology Q3).

56. Epigenetic DNA modification N6-methylAdesine inhibits DNA replication by DNA Polymerase ofPseudomonas aeruginosa Phage PaP1. Bianbian Li, Ke Du, Shiling Gu, Jiayu Xie, Tingting Liang,Zhongyan Xu, Hui Gao,Yihui Ling, Shuguang Lu, Zhen Sun*, and Huidong Zhang*. Chem. Res. Toxicol., 32: 840-849, 2019. DOI: 10.1021/acs.chemrestox.8b00348. (0893-228X, IF: 3.278; Cited 5 times; Toxicology Q2)

55. Epigenetically modified N6-methylAdesine inhibits DNA replication by human DNA Polymerase eta. Ke Du#, Xiangqian Zhang#, Zhenyu Zou, Bianbian Li, Shiling Gu, Shuming Zhang, Xiaoyi Qu, Yihui Ling, and Huidong Zhang*. DNA Repair, 2019, 78, 81-90. DOI: 10.1016/j.dnarep.2019.03.015. (1568-7864, IF: 4.461; Cited 7 times; Toxicology Q2)

54. lncRNA在女性生殖系統惡性腫瘤中的功能和作用機制。梁婷婷,米辰煬,謝嘉渝,許仲妍,楊舒,張慧東*。環境與職業醫學,2019, 36, 243-249.(應邀??涵h境和女性生殖健康)。

53. RNA的m6A修飾在女性生殖健康中的作用和機制。許仲妍#,謝嘉渝#,田震,梁婷婷,陳維娜,李雪瑩,王瑜陽,張慧東*。環境與職業醫學,2019, 36, 226-231.(應邀??涵h境和女性生殖健康)。

52. 多環芳烴暴露致女性生殖毒性及其分子機制。米辰煬,許仲妍,謝嘉渝,陳維娜,李雪瑩,方鑫*,張慧東*。環境與職業醫學,2019, 36, 43-49.(應邀??涵h境和女性生殖健康)。

51. "環境與女性生殖健康"專欄之序。張慧東。環境與職業醫學,2019, 36, 33-34.(應邀??涵h境和女性生殖健康,??M稿負責人)。

【2018】

50. Egg yolk immunoglobulins supplementation prevents rat liver from aflatoxin B1-induced oxidative damage and genotoxicity. Taotao Qiu, Xing Shen, Xiangmei Li, Yunyun Gong, Zhongmin Zou, Chunhong Liu, Feng Ye, Chenyang Mi, Zhenlin Xu, Yuanming Sun, Jie Lin, Huidong Zhang*, and Hongtao Lei*. J. Agric. Food Chem., 66: 13260-13267, 2018. DOI: 10.1021/acs.jafc.8b04659. (0021-8561, IF: 3.571; Cited 5 times; Agriculture Q1).

49. Benzo[a]pyrene-7,8-diol-9,10-epoxide suppresses the migration and invasion of human extravillous trophoblast Swan71 cells due to the inhibited filopodia formation and down-regulated PI3K/AKT/CDC42/PAK1 pathway mediated by the increased miR-194-3p. Zhen Tian#, Rong Wang#, Xi Zhang, Bin Deng, Chenyang Mi, Tingting Liang, Yihui Ling, Hongli Li, and Huidong Zhang*. Toxicol. Sci., 166: 25-38, 2018. DOI: 10.1093/toxsci/kfy182. (1096-6080, IF: 4.181; Cited 18 times; Medicine Q2)

48. Protein Interactions in T7 DNA Replisome Facilitate DNA Damage Bypass. Zhenyu Zou#, Ze Chen#, Qizhen Xue, Ying Xu, Jingyuan Xiong, Ping Yang, Shuai Le*, and Huidong Zhang*. ChemBioChem, 19, 1740-1749, 2018. DOI: 10.1002/cbic.201800203. (1439-4227, IF: 2.847; Cited 4 times; BiologyQ3)

47. Consecutive Ribonucleoside Monophosphates on Template Inhibit DNA Replication by T7 DNA Polymerase or by T7 Polymerase and Helicase Complex. Zhenyu Zou, Ze Chen, Yin Cai, Huang Yang, Ke Du, Bianbian Li, Yiguo Jiang, and Huidong Zhang*. Biochimie, 151: 128-138, 2018. https://doi.org/10.1016/j.biochi.2018.05.022. (0300-9084, IF: 3.362; Cited 5 times; Biochemistry & Molecular Biology Q3)

46. T7 helicase unwinding and stand switching investigated via single-molecular technology. Ze Chen, Jianbing Ma, Xingyuan Huang, Qi Jia, Chunhua Xu, Huidong Zhang* and Ying Lu*.? Acta Phys. Sin. 2018, 67: 118201.? (1000-3290; IF: 0.819: Q4).?

45. Pseudomonas aeruginosa MutL promotes large chromosomal deletions through non-homologous end joining to prevent bacteriophage predation. Mengyu Shen#, Huidong Zhang#, Shen Wei,Zhenyu Zou, Shuguang Lu, Gang Li,Xuesong He, Melissa Agnello, Wenyuan Shi*, Fuquan Hu*, and Shuai Le*. Nucleic Acids Res., 46: 4505-4514, 2018. DOI: 10.1093/nar/gky160. (0305-1048, IF: 11.561; Cited 20 times; Biology Q1)

44. General misincorporation frequency: re-evaluation of the fidelity of DNA polymerases. Jie Yang, Bianbian Li, Xiaoying Liu, Hong Tang, Xiyao Zhuang, Mingqi Yang, Ying Xu, Huidong Zhang*, and Chun Yang*. Biochem. Biophys. Res. Commun., 496: 1076-1081, 2018. DOI: https://doi.org/10.1016/j.bbrc.2018.01.135. (0006-291X, IF: 2.705; Cited 3 times; Biology Q3)

43. IgY reduces AFB1-induced cytotoxicity, cellular dysfunction, and genotoxicity in human L-02 hepatocytes and Swan 71 trophoblasts. Taotao Qiu, Xing Shen, Zhen Tian, Riming Huang, Xiangmei Li, Juan Wang, Rong Wang, Yuanming Sun, Yiguo Jiang, Hongtao Lei* and Huidong Zhang*. J. Agric. Food Chem., 66: 1543-1550, 2018. DOI: 10.1021/acs.jafc.7b05385. (0021-8561, IF: 3.571; Cited 9 times; Agriculture Q1)

42. Single-stranded DNA hybridization facilitated by T7 single-stranded DNA binding protein (gp2.5) rapidly initiates from the strandterminus or internally followed by a slow zippering step. Zhenyu Zou#, Siying Wu#, Jingyuan Xiong, Huangyuan Li, Yiguo Jiang, and Huidong Zhang*. Biochimie, 147: 1-12, 2018. DOI: 10.1016/j.biochi.2017.12.012. (0300-9084, IF: 3.362; Cited 5 times; Biochemistry & Molecular Biology Q3)

41. Bypass of an abasic site via the A-rule by DNA polymerase of Pseudomonas aeruginosa phage PaP1. Xiaoying Liu, Xiaoli Zou, Huangyuan Li, Zhenyu Zou, Jie Yang, Chenlun Wang,Shunhua Wu*, and Huidong Zhang*. Chem. Res. Toxicol.,31: 58-65, 2018. DOI: 10.1021/acs.chemrestox.7b00287. (0893-228X, IF: 3.278; Cited 9 times; Toxicology Q2)

【2017】

40. Benzo(a)pyren-7,8-dihydrodiol-9,10-epoxide induces human trophoblast Swan 71 cells dysfunctions due to cell apoptosis through disorder of mitochondrial fission/fusion. Weiping Wang, Rong Wang, Qiao Zhang, Gil Mor, and Huidong Zhang*. Environ. Pollut., 233: 820-832, 2017.DOI: 10.1016/j.envpol.2017.11.022. (0269-7491, IF: 6.792; Cited 31 times; Environmental science Q2)

39. ALX4, an epigenetically down regulated tumor suppressor, inhibits breast cancer progression by interfering Wnt/β-catenin pathway. Juntang Yang#, Fei Han#, Wenbin Liu, Hongqiang Chen, Xianglin Hao, Xiao jiang, Li Yin, Yongsheng Huang, Jia Cao, Huidong Zhang, and Jinyi Liu*. J. Exp. Clin. Cancer Res., 36: 170, 2017. DOI: 10.1186/s13046-017-0643-9. (1756-9966; IF: 5.646; Cited 17 times; Oncology Q2)

38. LHX6, an independent prognostic factor, inhibits lung adenocarcinoma progression through transcriptional silencing of β-catenin. Juntang Yang, Fei Han, Wenbin Liu, Mingqian Zhang, Yongsheng Huang, Xianglin Hao, Xiao Jiang, Li Yin, Hongqiang Chen, Jia Cao, Huidong Zhang* and Jinyi Liu*. J. Cancer, 8: 2561-2574, 2017. DOI: 10.7150/jca.19972. (1837-9664, IF: 3.249; Cited 7 times; Oncology Q3)

37. Error-prone bypass of O6-methylguanine by DNA polymerase of Pseudomonas aeruginosa phage PaP1. Shiling Gu#, Jingyuan Xiong#, Ying Shi, Jia You,Zhenyu Zou, Xiaoying Liu, and Huidong Zhang*. DNA Repair, 57: 35-44, 2017. DOI: http://dx.doi.org/10.1016/j.dnarep.2017.06.021. (1568-7864, IF: 4.461; Cited 15 times; Toxicology Q2)

36. Benzo[a]pyrene-7,8-diol-9,10-epoxide suppresses the migration and invasion of human extravillous trophoblast HTR-8/SVneo cells by down-regulating MMP2 through inhibition of FAK/SRC/PI3K/AKT/eNOS pathway. Rong Wang, Weiping Wang, Lin Ao, Zi Wang, Xianglin Hao, and Huidong Zhang*. Toxicology, 386: 72-83, 2017. DOI: http://dx.doi.org/10.1016/j.tox.2017.05.008. (0300-483X, IF: 3.817; Cited 31 times; Toxicology Q2)

35. Error-free bypass of 7,8-dihydro-8-oxo-2’-deoxyguanosine by DNA polymerase of Pseudomonas aeruginosa phage PaP1. Shiling Gu, Qizhen Xue, Qin Liu, Mei Xiong, Wanneng Wang*, and Huidong Zhang*. Genes, 8: 18, 2017. DOI: 10.3390/genes8010018. (Invited; 2073-4425; IF: 3.331; Cited 15 times; Genetics & Heredity Q2)

34. Low-concentration serum promotes the adhesion andspreading of mouse fibroblast L929 cell onhydrophobic glass surface. Weiping Wang#, Rong Wang#,Peng Qin#, Huan Yang, Changguo Ma, Fan Zhang, Qiao Zhang*, Yuehua Cui*, and HuidongZhang*.J. Biomater. Tissue Eng., 7: 333-342, 2017. DOI: https://doi.org/10.1166/jbt.2017.1572. (2157-9083; IF: 2.066; Cited 3 times; Cell & Tissue Engineering Q4)

【2016】

33. Pseudomonas aeruginosa phage PaP1 DNA polymerase is an A-family high processive DNA polymerase with ssDNA and dsDNA 3¢ to 5¢ exonuclease activity. Binyan Liu, Shiling Gu, Nengsong Liang, Mei Xiong, Qizhen Xue, Shuguang Lu, Fuquan Hu, and Huidong Zhang*. Virus Genes, 52:538-551, 2016. DOI:10.1007/s11262-016-1329-7. (IF: 1.845; Cited 10 times; virus Q4)

32. Kinetic analysis of bypass of O6-methylguanine by the catalytic core of yeast DNA polymerase eta. Binyan Liu#, Qizhen Xue#, Shiling Gu,Weiping Wang, Jie Chen, Yingqing Li, Chunxue Wang, and Huidong Zhang*.Arch. Biochem. Biophys., 596: 99-107, 2016. DOI:10.1016/j.abb.2016.03.009. (0003-9861, IF: 3.559; Cited 16 times; Biochemistry & Molecular Biology Q3)

31. Mechanisms of mutagenesis: DNA replication in the presence of DNA damage.Binyan Liu, Qizhen Xue, Yong Tang, Jia Cao, F. Peter Guengerich, and Huidong Zhang*. Mutat. Res. Rev.,768: 53-67, 2016. DOI:10.1016/j.mrrev.2016.03.006. (Invited; 1383-5742, IF: 6.213; Cited 37 times; Toxicology Q1).?

30. Kinetic analysis of bypass of 7,8-dihydro-8-oxo-2′-deoxyguanosine by the catalytic core of yeast DNA polymerase eta. Qizhen Xue#, Mengyu Zhong#, Binyan Liu, Yong Tang, Zeliang Wei, F. Peter Guengerich, and Huidong Zhang*. Biochimie, 121: 161-169, 2016. DOI:10.1016/j.biochi.2015.12.009. (0300-9084, IF:3.362; Cited 15 times; Biochemistry & Molecular Biology Q3)

29. Binding affinities among helicase, DNA polymerase and replication intermediate DNA in the T7 DNA replisome. Huidong Zhang*,Yong Tang, Seung-Joo Lee, Zeliang Wei, Jia Cao, and Charles C. Richardson*. J. Biol. Chem., 291: 1472-1480, 2016. DOI:10.1074/jbc.M115.698233. (0021-9258, IF:4.573; Cited 19 times; Biology Q2)

【2015】

28. DNA Replication-Damage from Environmental Carcinogens. Huidong Zhang*. Invited Briefs, Springer Briefs in Biochemistry and Molecular Biolgy, 2015, 1-51. (Invited)

27. Kinetic analysis of bypass of abasic site by the catalytic core of yeast DNA polymerase eta. Juntang Yang#, Rong Wang#, Binyan Liu, Qizhen Xue, Mengyu Zhong, Hao Zeng, and Huidong Zhang*. Mutat. Res.-Fund. Mol. M., 779: 134-143, 2015. DOI: 10.1016/j.mrfmmm.2015.07.001. (0027-5107, IF: 3.680; Cited 15 times; Toxicology Q2)

【2014】

26. Epigenetic regulation of SOX30 is associated with testis development in mice. Fei Han, Yan Dong, Wenbin Liu, Xuexiang Ma, Ronghui Shi, Hongqiang Chen, Zhihong Cui, Lin Ao, Huidong Zhang, Jia Cao, and Jinyi Liu*. PLoS One, 9(5): e97203, 2014. DOI:10.1371/Journal.pone.0097203. (1932-6203, IF: 3.234; Cited 35 times; Multidisciplinary Sciences Q2)

【2012】

25. Heterohexamer of 56- and 63-kDa gene 4 helicase-primase of bacteriophage T7 in DNA replication. Huidong Zhang#, Seung-Joo Lee, Arkadiusz W. Kulczyk, Bin Zhu, and Charles C. Richardson*. J. Biol. Chem.,287: 34273-34287, 2012. DOI:10.1074/jbc.M112.401158. (0021-9258, IF: 5.328; Cited 11 times; Biology Q2)

24. The roles of tryptophans in primer synthesis by the DNA primase of bacteriophage T7. Huidong Zhang#, Seung-Joo Lee#, and Charles C. Richardson*. J. Biol. Chem.,287: 23644-23656, 2012.DOI:10.1074/jbc.M112.366096. (0021-9258, IF: 5.328; Cited 8 times; Biology Q2)

【2011】

23. Essential protein interactionswithin the replisome regulate DNA replication. Huidong Zhang, Seung-Joo Lee, and Charles C. Richardson*. Cell Cycle, 10:3413-3414, 2011. DOI:10.4161/cc.10.20.17523. (Invited feature article;1538-4101, ?IF: 5.359; Cited 6 times; Cell Biology Q2)

22. Helicase-DNA polymerase interaction is critical to initiate leading-strand DNA synthesis. Huidong Zhang#,Seung-Joo Lee#, Bin Zhu, Ngoc Q. Tran, Stanley Tabor, and Charles C. Richardson*. Proc. Natl. Acad. Sci. USA, 108:9372-9377, 2011. DOI:10.1073/pnas.1106678108. (0027-8424, IF: 10.591; Cited 54 times; Multidisciplinary Sciences Q1)

【2010】

21. Steric and electrostatic effects at the C2 atom substituent influence replication and miscoding of the DNA deamination product deoxyxanthosine and analogs by DNA polymerases. Huidong Zhang, Urban Bren, Ivan D. Kozekov, Carmelo J. Rizzo, Donald F. Stec, and F. Peter Guengerich*. 238th American-Chemical-Society National Meeting. Washington, DC.AUG 16-20, 2009. Chem. Res. Toxicol., 23: 275-275, 2010. (0893-228X, IF: 4.148; Chemistry, Medicinal Q2; 0 times)

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20. Effect of N2-guanyl modifications on early steps in catalysis of polymerization by Sulfolobus solfataricus P2 DNA polymerase Dpo4 T239W. Huidong Zhang and F. Peter Guengerich*. J. Mol. Biol.,395:1007-1018, 2010.DOI:10.1016/j.jmb.2009.11.071. (0022-2836, IF: 4.008; Cited 29 times; Biochemistry & Molecular Biology Q2)

【2009】

19. Frameshift deletion by Sulfolobus solfataricus P2 DNA polymerase Dpo4 T239W is selective for purines and involves normal conformational change followed by slow phosphodiester bond formation. Huidong Zhang, Jeff W. Beckman, and F. Peter Guengerich*. J. Biol. Chem.,284:35144-35153, 2009. DOI: 10.1074/jbc.M109.067397. (0021-9258, IF: 5.328; Cited 13 times; Biology Q2)

18. Steric and electrostatic effects at the C2 atom substituent influence replication and miscoding of the DNA deamination product deoxyxanthosine and analogs by DNA polymerases. Huidong Zhang, Urban Bren, Ivan D. Kozekov,Carmelo J. Rizzo, Donald F. Stec, and F. Peter Guengerich*. J. Mol. Biol., 392:251-269, 2009. DOI: 10.1016/j.jmb.2009.07.019. (0022-2836, IF: 4.008; Cited 26 times; Biochemistry & Molecular Biology Q1)

17. Structure-function relationships in miscoding by Sulfolobus solfataricus DNA polymerase Dpo4. Guanine N2, N2-dimethyl substitution produces inactive and miscoding polymerase complexes. Huidong Zhang#, Robert L. Eoff#, Ivan D. Kozekov, Carmelo J. Rizzo,Martin Egli, and F. Peter Guengerich*. J. Biol. Chem., 284:17687-17699, 2009.DOI: 10.1074/jbc.M109014274. (0021-9258, IF: 5.328; Cited 33 times; Biology Q2)

16. Versatility of Y-family sulfolobus solfataricus DNA polymerase Dpo4 in translesion synthesis past bulky N2-alkyl guanine adducts. Huidong Zhang#,Robert L. Eoff#, Ivan D. Kozekov, Carmelo J. Rizzo,Martin Egli, and F. Peter Guengerich*. J. Biol. Chem.,284:3563-3576, 2009. DOI: 10.1074/jbc.M807778200. (Cover paper; 0021-9258, ?IF: 5.328; Cited 53 times; Biology Q2)

【2008】

15. Effect of N2-alkylguanine adducts on replication by Y-class Sulfolobus solfataricus DNA Polymerase Dpo4. Huidong Zhang, Robert L. Eoff, Karen C. Angel, and F. Peter Guengerich*. 236th National Meeting of the American-Chemical-Society. Philadelphia, PA. AUG 17-21, 2008. Chem. Res. Toxicol., 21: 2443, 2008. (0893-228X, IF: 4.148; Cited 1 times; Toxicology Q2)

14. Template enhanced activity of lipase accommodated in siliceous mesocellular foams. Yanmei Zhang, Lifang Zhao, Jun Li, Huidong Zhang, Liangyu Zheng, Shugui Cao*, and Can Li*. Biochem. Biophys. Res. Commun.,372:650-655, 2008. DOI: 10.1016/j.bbrc.2008.05.089. (0006-291X, IF: 3.297; Cited 16 times; Biochemistry & Molecular Biology Q3)

13. Asymmetric hydroformylation of olefins catalyzed by rhodium nanoparticles chirally stabilized with (R)-BINAP ligand. Difei Han, Xiaohong Li, Huidong Zhang, Zhimin Liu, Gengshen Hu, and Can Li*. J. Mol. Catal. A: Chem., 283:15-22, 2008. DOI: 10.1016/j.molcata.2007.12.008. (1381-1169, IF: 3.160; Cited 49 times; Chemistry, Physical Q3)

12. An efficient resolution of racemic secondary alcohols on magnetically separable biocatalyst. Yanmei Zhang, Jun Li, Difei Han, Huidong Zhang, Peng Liu, and Can Li*. Biochem. Biophys. Res. Commun., 365: 609-613, 2008. DOI: 10.1016/j.bbrc.2007.10.205.(0006-291X, IF: 2.297; Cited 45 times; Biochemistry & Molecular BiologyQ3)

【2007】

11. Kinetic study of the catalytic reforming of CH4 with CO2 to syngas over Ni/ alpha-Al2O3 catalyst: The effect of temperature on the reforming mechanism. Yuehua Cui, Huidong Zhang, Hengyong Xu*, and Wenzhao Li. Appl. Catal. A: Gen., 318:79-88, 2007. DOI: 10.1016/j.apcata.2006.10.044. (0926-860X, IF: 3.942; Cited 90 times; Environmental Sciences Q2)

10. The CO2 reforming of CH4 over Ni/La2O3/alpha-Al2O3 catalysts: The effect of La2O3 contents on the kinetic performance. Yuehua Cui, Huidong Zhang, Hengyong Xu*, and Wenzhao Li. Appl. Catal. A: Gen., 331: 60-69, 2007. DOI: 10.1016/j.apcata.2007.06.039. (0926-860X, IF: 3.942; Cited 72 times; Environmental Sciences Q2)

9. Kinetic depressing the deposition of carbon species on Ni-based catalysts: La2O3 adjusts the reaction rates of CO2 higher than CH4 by tuning the Ea and pre-exponential factor. Yuehua Cui, Huidong Zhang, Hengyong Xu*, Qingjie Ge, Yuzhong Wang, Shoufu Hou, and Wenzhao Li. Stud. Surf. Sci. Catal., 167: 281-286, 2007. ?DOI: 10.1016/S0167-2991(07)80145-5 (Cited 2 times)

8. Chiral synthesis on catalysts in nanopores. Can Li*, Huidong Zhang, Dongmei Jiang, and Qihua Yang. Chem. Commun., 6: 547-558, 2007. DOI: 10.1039/b609862b. (Invited feature article; 1359-7345,? IF: 6.169; Cited 197 times; Chemistry Q1)

【2006】

7. Heterogeneous asymmetric hydroformylation of olefins on chirally modified Rh/SiO2 catalysts. Difei Han, Xiaohong Li, Huidong Zhang, Zhimin Liu, Jun Li, and Can Li*. J. Catal., 243: 318-328, 2006. DOI: 10.1016/j.jcat.2006.08.003. (0021-9517, IF: 6.201; Cited 66 times; Chemistry, Physical Q1)

6. Asymmetric epoxidation of 6-cyano-2,2-dimethylchromene on Mn(salen) catalyst immobilized in mesoporous materials. Huidong Zhangand Can Li*. Tetrahedron, 62: 6640-6649, 2006. DOI:10.1016/j.tet.2006.01.117. (Invited paper; 0040-4020, ?IF: 3.060; Cited 83 times; Chemistry, Organic Q3)

5. Enantioselective epoxidation of unfunctional olefins catalyzed by the Mn(salen) catalysts immobilized in the nanopores of mesoporous materials. Huidong Zhang,Yanmei Zhang, and Can Li*. J. Catal., 238: 369-381, 2006. DOI: 10.1016/j.jcat.2005.12.023.(0021-9517, IF: 6.201; Cited 131 times; Chemistry, Physical Q1)

2005

4. Asymmetric epoxidation of unfunctional olefins catalyzed by Mn(salen) axially immobilized onto insoluble polymers. Huidong Zhang,Yanmei Zhang, and Can Li*. Tetrahedron: Asymmetry, 16: 2417-2423, 2005. DOI: 10.1016/j.tetasy.2005.05.034. (IF: 2.652; Cited 44 times; Chemistry, Organic Q3)

3. Heterogeneous enantioselective epoxidation catalyzed by Mn(salen) complexes grafted onto mesoporous materials by phenoxyl group. Huidong Zhang, Song Xiang, Jianliang Xiao, and Can Li*. J. Mol. Catal. A: Chem., 238: 175-184, 2005. DOI: 10.1016/j.molcata.2005.05.024. (1381-1169, IF: 3.160; Cited 85 times; Chemistry, Physical Q3)

2. Enantioselective epoxidation of unfunctional olefins catalyzed by Mn(salen) complexes immobilized in porous materials via phenyl sulfonic group. Huidong Zhang,Song Xiang, and Can Li*. Chem. Commun., 1209-1211, 2005. DOI: 10.1039/b417041e. (1359-7345, IF: 6.169; Cited 145 times; Chemistry Q1)

1. The surface sites of sulfated zirconia studied in situ by laser-induced fluorescence spectroscopy. Jun Chen, Zhaochi Feng, Jianying Shi, Pinliang Ying, Huidong Zhang, and Can Li*. Chem. Phys. Lett., 401: 104-108, 2005. DOI: 10.1016/ j.cplett.2004.11.039. (0009-2614, IF: 1.897; Cited 5 times; Physics, Atomic, Molecular & Chemical Q3)

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